Synthetic Nicotine

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A Box of Killer Sweets White Gummy Vapetasia Synthetic eLiquid with a warning sign and a 100ml bottle next to it - Vape Juice Depot
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A 100ml bottle of Melonberry Milk Moo eLiquids with a warning sign - Vape Juice Depot
Kilo Melonberry Milk Moo eLiquids 100ml
Sale price$ 12.98
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A 60ml bottle of Pure Mango AQUA Synthetic eLiquid and a box with a warning sign - Vape Juice Depot
AQUA Pure Mango AQUA Synthetic eLiquid 60ml
Sale price$ 9.99
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A 120ml bottle of Iced Out Ruthless Freeze Edition with a warning sign - Vape Juice Depot
Ruthless Iced Out Ruthless Freeze Edition 120ml
Sale price$ 13.49
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A 30ml bottle of Blue Razz Freeze Hyde Pod Juice TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice Blue Razz Freeze Hyde Pod Juice TFN Salt 30ml
Sale price$ 11.98
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A 60ml bottle of Blackberry Crumble Dinner Lady TFN 3mg with a warning sign - Vape Juice Depot
Dinner Lady Blackberry Crumble Dinner Lady TFN 60ml
Sale price$ 11.59
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A box of Blue Raspberry Lemon TFN Salts Cloud Nurdz with a warning sign and a 30ml bottle next to it - Vape Juice Depot
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A box of Funnel Cake FRYD TFN eLiquid and a 120ml bottle with a warning sign next to it - Vape Juice Depot
FRYD eLiquids Funnel Cake FRYD TFN eLiquid 120ml
Sale price$ 18.78
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A box of ICED Strawberry Mango TFN Cloud Nurdz with a warning sign and a 100ml bottle next to it - Vape Juice Depot
Cloud Nurdz ICED Strawberry Mango TFN Cloud Nurdz 100ml
Sale price$ 12.49
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Three Flavors of Aloha Sun TFN 7000 Disposable - Vape Juice Depot
Aloha Sun Aloha Sun TFN 7000 Disposable
Sale price$ 12.99
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Description

Synthetic nicotine is created in a laboratory rather than from tobacco leaves. Though synthetic nicotine has been around for some time, it has only recently started being used in products such as e-cigarettes as the production costs have gone down. It is produced as a liquid, which has found its way primarily into vape products.

Research on the safety of synthetic nicotine is ongoing. Despite not being derived from tobacco, synthetic nicotine may still pose risks. Scientists are investigating its health impacts, with existing knowledge indicating that specific flavor components could adversely affect health. Products that use synthetic nicotine, on the other hand, have the same or similar amounts of nicotine in them as tobacco-derived products.

Synthetic nicotine is crafted in laboratories through various chemical processes, yielding either pure S-nicotine or a 50:50 racemic mixture of S-nicotine and R-nicotine.

As detailed in a patent by Next Generation Labs, one method begins with ethyl nicotinate, an ester of niacin, which is transformed into myosmine, a tobacco alkaloid, and then reduced to nornicotine. This compound is further methylated to produce a racemic mix of S-nicotine and R-nicotine. Contraf-Nicotex-Tobacco (CNT), another major supplier, separates racemic nicotine mixtures or prepares enantiomerically pure substances using specialized processes.

Alternatively, Zanoprima employs myosmine as the starting material, converting it into S-nor nicotine using recombinant enzymes before methylation yields S-nicotine. Despite innovation and scaling production, synthetic nicotine remains three to four times more costly than tobacco-derived nicotine, although prices are gradually decreasing. The primary challenge lies in labeling and distinguishing synthetic nicotine from its tobacco-derived counterparts.

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