Synthetic Nicotine

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A 30ml bottle of Banana Freeze Pod Juice TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice
 Banana Freeze Pod Juice TFN Salt 30ml
$ 11.98
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A 30ml bottle of Jewel Mint Lush Freeze Pod Juice TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice
 Jewel Mint Lush Freeze Pod Juice TFN Salt 30ml
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A 30ml bottle of FLOW AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA
 FLOW AQUA Synthetic Salts 30ml
$ 9.19 $ 11.49
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A box of ICED Watermelon Apple Cloud Nurdz and a 100ml bottle with a warning sign next to it - Vape Juice Depot
Cloud Nurdz
 ICED Apple Watermelon TFN Cloud Nurdz 100ml
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A box of ICED Peach Blue Razz TFN Cloud Nurdz with a warning sign and a 100ml bottle next to it - Vape Juice Depot
Cloud Nurdz
 ICED Blue Raspberry Peach TFN Cloud Nurdz 100ml
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A 30ml bottle of Hawaiian Pod Juice TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice
 Hawaiian Pod Juice TFN Salt 30ml
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A 30ml bottle of Classic Menthol I Love Salts by Mad Hatter with a warning sign - Vape Juice Depot
Mad Hatter Juice
 Classic Menthol I Love Salts by Mad Hatter 30ml
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A 60ml bottle of MIST AQUA Original eLiquid with a warning sign and a box next to it - Vape Juice Depot
AQUA
 MIST AQUA Original eLiquid 60ml
$ 11.49
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A 30ml bottle of SWELL AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA
 SWELL AQUA Synthetic Salts 30ml
$ 9.19 $ 11.49
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A 30ml bottle of RUSH AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA
 RUSH AQUA Synthetic Salts 30ml
$ 9.19 $ 11.49
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A 60ml bottle of Menthol Pure AQUA eLiquid with a warning sign and a box next to it - Vape Juice Depot
AQUA
 Menthol Pure AQUA eLiquid 60ml
$ 11.49
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A 60ml bottle of RUSH AQUA Fresh eLiquid with a warning sign and a box next to it - Vape Juice Depot
AQUA
 RUSH AQUA Fresh eLiquid 60ml
$ 11.49
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Description

Plants in the nightshade family related to tomatoes, eggplant, and belladonna flowers derive synthetic nicotine. These natural sources offer a more eco friendly and sustainable nicotine vape option than tobacco-based nicotine. In addition, with a patented extraction method, this type of nicotine creates vapeable products without using tobacco plants.

The multi step creation process includes using natural starter material from approved sources, with all points of production occurring in a cGMP (Current Good Manufacturing Process) certified laboratory. Mainly, synthetic nicotine, also known as tobacco free nicotine, is tasteless and odorless for consumers. Meaning that eLiquids made with it are cleaner and crisper in taste but still provide the familiar ‘nicotine buzz’ feeling.

Here we offer various nicotine free vape products with synthetic nicotine liquid, which offers many benefits and more purity than synthetic-based nicotine, so you can enjoy a cleaner and tasty vaping experience while helping the planet by supporting an eco friendly source. You can find products from brands like AQUA, Cloud Nurdz, Ripe Vapes, Pod Juice, and more.

Synthetic nicotine is created in a laboratory rather than from tobacco leaves. Though synthetic nicotine has been around for some time, it has only recently started being used in products such as e-cigarettes as the production costs have gone down. It is produced as a liquid, which has found its way primarily into vape products.

Research on the safety of synthetic nicotine is ongoing. Despite not being derived from tobacco, synthetic nicotine may still pose risks. Scientists are investigating its health impacts, with existing knowledge indicating that specific flavor components could adversely affect health. Products that use synthetic nicotine, on the other hand, have the same or similar amounts of nicotine in them as tobacco-derived products.

Synthetic nicotine is crafted in laboratories through various chemical processes, yielding either pure S-nicotine or a 50:50 racemic mixture of S-nicotine and R-nicotine.

As detailed in a patent by Next Generation Labs, one method begins with ethyl nicotinate, an ester of niacin, which is transformed into myosmine, a tobacco alkaloid, and then reduced to nornicotine. This compound is further methylated to produce a racemic mix of S-nicotine and R-nicotine.
Contraf-Nicotex-Tobacco (CNT), another major supplier, separates racemic nicotine mixtures or prepares enantiomerically pure substances using specialized processes.

Alternatively, Zanoprima employs myosmine as the starting material, converting it into S-nor nicotine using recombinant enzymes before methylation yields S-nicotine. Despite innovation and scaling production, synthetic nicotine remains three to four times more costly than tobacco-derived nicotine, although prices are gradually decreasing.
The primary challenge lies in labeling and distinguishing synthetic nicotine from its tobacco-derived counterparts.