Synthetic Nicotine

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A box of Blue Razz Lemon ICED TFN Salts Cloud Nurdz and a 30ml bottle with a warning sign next to it - Vape Juice Depot
Cloud Nurdz
 Blue Raspberry Lemon ICED TFN Salts Cloud Nurdz 30ml
$ 11.99
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A box of Pure Melon AQUA Synthetic Salts with a warning sign and a 30ml bottle next to it - Vape Juice Depot
AQUA
 Pure Melon AQUA Synthetic Salts 30ml
$ 7.99 $ 9.99
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A 60ml bottle of Strawberry Cream Coastal Clouds TFN and a box with a warning sign next to it - Vape Juice Depot
Coastal Clouds
 Strawberry Cream Coastal Clouds TFN 60ml
From $ 11.49
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A 30ml bottle of Strawberry Kiwi Coastal Clouds Salts TFN and a box with a warning sign next to it - Vape Juice Depot
Coastal Clouds
 Strawberry Kiwi Coastal Clouds Salts TFN 30ml
$ 12.99
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A box of Strawberry Kiwi TFN Cloud Nurdz with a warning sign and a 100ml bottle next to it - Vape Juice Depot
Cloud Nurdz
 Strawberry Kiwi TFN Cloud Nurdz 100ml
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A box of Brown Tobacco Glas Basix Series with a warning sign and a 60ml bottle next to it - Vape Juice Depot
Glas Vapor
 Brown Tobacco Glas Basix Series 60ml
$ 9.33 $ 10.98
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A 30ml bottle of PBLS Salts Glas Basix - Vape Juice Depot
Glas Vapor
 PBLS Glas Basix Salts 30ml
$ 9.33 $ 10.98
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A 30ml bottle of WHIRLWIND AQUA Synthetic Salts 36mg with a warning sign and a box next to it - Vape Juice Depot
AQUA
 WHIRLWIND AQUA Synthetic Salts 30ml
$ 7.99 $ 9.99
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A 30ml bottle of Jewel Mint Emerald Pod Juice TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice
 Jewel Mint Emerald Pod Juice TFN Salt 30ml
$ 11.95
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Peach Ice Salts YOGI Delights 30ml
YOGI
 Peach Ice Salts YOGI Delights 30ml
$ 11.98
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A box of Cool Melon Glas Basix Series with a warning sign and a 60ml bottle next to it - Vape Juice Depot
Glas Vapor
 Cool Melon Glas Basix Series 60ml
$ 4.24 $ 4.99
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A 30ml bottle of Menthol Polar AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA
 Menthol Polar AQUA Synthetic Salts 30ml
$ 9.19 $ 11.49
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Description

Plants in the nightshade family related to tomatoes, eggplant, and belladonna flowers derive synthetic nicotine. These natural sources offer a more eco friendly and sustainable nicotine vape option than tobacco-based nicotine. In addition, with a patented extraction method, this type of nicotine creates vapeable products without using tobacco plants.

The multi step creation process includes using natural starter material from approved sources, with all points of production occurring in a cGMP (Current Good Manufacturing Process) certified laboratory. Mainly, synthetic nicotine, also known as tobacco free nicotine, is tasteless and odorless for consumers. Meaning that eLiquids made with it are cleaner and crisper in taste but still provide the familiar ‘nicotine buzz’ feeling.

Here we offer various nicotine free vape products with synthetic nicotine liquid, which offers many benefits and more purity than synthetic-based nicotine, so you can enjoy a cleaner and tasty vaping experience while helping the planet by supporting an eco friendly source. You can find products from brands like AQUA, Cloud Nurdz, Ripe Vapes, Pod Juice, and more.

Synthetic nicotine is created in a laboratory rather than from tobacco leaves. Though synthetic nicotine has been around for some time, it has only recently started being used in products such as e-cigarettes as the production costs have gone down. It is produced as a liquid, which has found its way primarily into vape products.

Research on the safety of synthetic nicotine is ongoing. Despite not being derived from tobacco, synthetic nicotine may still pose risks. Scientists are investigating its health impacts, with existing knowledge indicating that specific flavor components could adversely affect health. Products that use synthetic nicotine, on the other hand, have the same or similar amounts of nicotine in them as tobacco-derived products.

Synthetic nicotine is crafted in laboratories through various chemical processes, yielding either pure S-nicotine or a 50:50 racemic mixture of S-nicotine and R-nicotine.

As detailed in a patent by Next Generation Labs, one method begins with ethyl nicotinate, an ester of niacin, which is transformed into myosmine, a tobacco alkaloid, and then reduced to nornicotine. This compound is further methylated to produce a racemic mix of S-nicotine and R-nicotine.
Contraf-Nicotex-Tobacco (CNT), another major supplier, separates racemic nicotine mixtures or prepares enantiomerically pure substances using specialized processes.

Alternatively, Zanoprima employs myosmine as the starting material, converting it into S-nor nicotine using recombinant enzymes before methylation yields S-nicotine. Despite innovation and scaling production, synthetic nicotine remains three to four times more costly than tobacco-derived nicotine, although prices are gradually decreasing.
The primary challenge lies in labeling and distinguishing synthetic nicotine from its tobacco-derived counterparts.