Synthetic Nicotine

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A 120ml bottle of Strawberry Crepe TFN Humble eLiquid and a box with a warning sign next to it - Vape Juice Depot
Humble Juice Co
 Strawberry Crepe (Strawberry Waffle) TFN Humble 120ml
From $ 11.49
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A 30ml bottle of Peach Berry Pod Juice PJ 5000 Series TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice
 Peach Berry Pod Juice PJ5000 TFN Salt 30ml
$ 11.98
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A 30ml bottle of Cuban Blend Naked Synthetic Salt and a box with a warning sign - Vape Juice Depot
Naked 100
 Cuban Blend Naked Synthetic Salt 30ml
$ 10.98
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A 100ml bottle of Pineapple Whip Kilo Revival TFN eLiquid and a box with a warning sign next to it - Vape Juice Depot
Kilo
 Pineapple Whip Kilo Revival TFN eLiquid 100ml
$ 12.99
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A 30ml bottle of Kiwi Dragon Berry Pod Juice PJ 5000 Series TFN Salt and a box with a warning sign next to it - Vape Juice Depot
Pod Juice
 Kiwi Dragon Berry Pod Juice PJ5000 TFN Salt 30ml
$ 11.98
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A box of Cherry Drank Ruthless Vapor and 100ml bottle next to it - Vape Juice Depot
Ruthless
 Cherry Drank Ruthless Vapor 100ml
From $ 12.99
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A box of Jax The Milk TFN eLiquid with a warning sign and a 100ml bottle next to it - Vape Juice Depot
Jam Monster
 Jax The Milk TFN eLiquid 100ml
From $ 12.59
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A 30ml bottle of Menthol Arctic AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA
 Menthol Arctic AQUA Synthetic Salts 30ml
$ 11.49
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A 100ml bottle of Cereal Milk Kilo Revival TFN eLiquid and a box with a warning sign next to it - Vape Juice Depot
Kilo
 Cereal Milk Kilo Revival TFN eLiquid 100ml
$ 12.99
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A 30ml bottle of Blue Razz Jam Pod Juice TFN Salt with a warning sign - Vape Juice Depot
Pod Juice
 Blue Razz Jam Pod Juice TFN Salt 30ml
$ 9.98
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A 30ml bottle of Strazz Pod Juice PJ 5000 Series TFN Salt and a box with a warning sign - Vape Juice Depot
Pod Juice
 Starzz Pod Juice PJ5000 TFN Salt 30ml
$ 11.98
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A 120ml bottle of Iced Out Ruthless Freeze Edition with a warning sign - Vape Juice Depot
Ruthless
 Iced Out Ruthless Freeze Edition 100ml
From $ 13.49
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Description

Plants in the nightshade family related to tomatoes, eggplant, and belladonna flowers derive synthetic nicotine. These natural sources offer a more eco friendly and sustainable nicotine vape option than tobacco-based nicotine. In addition, with a patented extraction method, this type of nicotine creates vapeable products without using tobacco plants.

The multi step creation process includes using natural starter material from approved sources, with all points of production occurring in a cGMP (Current Good Manufacturing Process) certified laboratory. Mainly, synthetic nicotine, also known as tobacco free nicotine, is tasteless and odorless for consumers. Meaning that eLiquids made with it are cleaner and crisper in taste but still provide the familiar ‘nicotine buzz’ feeling.

Here we offer various nicotine free vape products with synthetic nicotine liquid, which offers many benefits and more purity than synthetic-based nicotine, so you can enjoy a cleaner and tasty vaping experience while helping the planet by supporting an eco friendly source. You can find products from brands like AQUA, Cloud Nurdz, Ripe Vapes, Pod Juice, and more.

Synthetic nicotine is created in a laboratory rather than from tobacco leaves. Though synthetic nicotine has been around for some time, it has only recently started being used in products such as e-cigarettes as the production costs have gone down. It is produced as a liquid, which has found its way primarily into vape products.

Research on the safety of synthetic nicotine is ongoing. Despite not being derived from tobacco, synthetic nicotine may still pose risks. Scientists are investigating its health impacts, with existing knowledge indicating that specific flavor components could adversely affect health. Products that use synthetic nicotine, on the other hand, have the same or similar amounts of nicotine in them as tobacco-derived products.

Synthetic nicotine is crafted in laboratories through various chemical processes, yielding either pure S-nicotine or a 50:50 racemic mixture of S-nicotine and R-nicotine.

As detailed in a patent by Next Generation Labs, one method begins with ethyl nicotinate, an ester of niacin, which is transformed into myosmine, a tobacco alkaloid, and then reduced to nornicotine. This compound is further methylated to produce a racemic mix of S-nicotine and R-nicotine.
Contraf-Nicotex-Tobacco (CNT), another major supplier, separates racemic nicotine mixtures or prepares enantiomerically pure substances using specialized processes.

Alternatively, Zanoprima employs myosmine as the starting material, converting it into S-nor nicotine using recombinant enzymes before methylation yields S-nicotine. Despite innovation and scaling production, synthetic nicotine remains three to four times more costly than tobacco-derived nicotine, although prices are gradually decreasing.
The primary challenge lies in labeling and distinguishing synthetic nicotine from its tobacco-derived counterparts.