Synthetic Nicotine

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A 30ml bottle of OASIS AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA OASIS AQUA Synthetic Salts 30ml
Sale price$ 11.49
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A 30ml bottle of Peach Freeze Pod Juice TFN Salt with a warning sign - Vape Juice Depot
Pod Juice Peach Freeze Pod Juice TFN Salt 30ml
Sale price$ 11.98
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A 60ml bottle of VCT Bold Ripe Vapes eLiquid with a warning sign - Vape Juice Depot
Ripe Vapes VCT Bold Ripe Vapes eLiquid 60ml/120ml
Sale price$ 12.99
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A 30ml bottle of MIST AQUA Synthetic Salts 35mg with a warning sign and a box next to it - Vape Juice Depot
AQUA MIST AQUA Synthetic Salts 30ml
Sale price$ 11.49
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A box of Butterscotch Reserve Glas Basix Series with a warning sign and a 60ml bottle next to it - Vape Juice Depot
Glas Vapor Butterscotch Reserve Glas Basix Series 60ml
Sale price$ 10.49
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A 30ml bottle of Pink Burst Pod Juice Nicotine Salt with a warning sign - Vape Juice Depot
Pod Juice Pink Burst Pod Juice TFN Salt 30ml
Sale price$ 11.98
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A 30ml bottle of Cola Freeze TFN Salt Pod Juice with a warning sign - Vape Juice Depot
Pod Juice Cola Freeze TFN Salt Pod Juice 30ml
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A 30ml bottle of Fuji PachaMama Salts and a box with a warning sign next to it - Vape Juice Depot
PachaMama Fuji PachaMama Syn Salts 30ml
Sale price$ 10.98
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A box of Caribbean Punch Glas Basix Series with a warning sign and a 60ml bottle next to it - Vape Juice Depot
Glas Vapor Caribbean Punch Glas Basix Series 60ml
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4 flavors of 7 Daze OHMLET 7000 Disposable - Vape Juice Depot
Reds 7 Daze OHMLET 7000 Disposable
Sale price$ 4.99 Regular price$ 12.98
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Synthetic nicotine is created in a laboratory rather than from tobacco leaves. Though synthetic nicotine has been around for some time, it has only recently started being used in products such as e-cigarettes as the production costs have gone down. It is produced as a liquid, which has found its way primarily into vape products.

Research on the safety of synthetic nicotine is ongoing. Despite not being derived from tobacco, synthetic nicotine may still pose risks. Scientists are investigating its health impacts, with existing knowledge indicating that specific flavor components could adversely affect health. Products that use synthetic nicotine, on the other hand, have the same or similar amounts of nicotine in them as tobacco-derived products.

Synthetic nicotine is crafted in laboratories through various chemical processes, yielding either pure S-nicotine or a 50:50 racemic mixture of S-nicotine and R-nicotine.

As detailed in a patent by Next Generation Labs, one method begins with ethyl nicotinate, an ester of niacin, which is transformed into myosmine, a tobacco alkaloid, and then reduced to nornicotine. This compound is further methylated to produce a racemic mix of S-nicotine and R-nicotine.
Contraf-Nicotex-Tobacco (CNT), another major supplier, separates racemic nicotine mixtures or prepares enantiomerically pure substances using specialized processes.

Alternatively, Zanoprima employs myosmine as the starting material, converting it into S-nor nicotine using recombinant enzymes before methylation yields S-nicotine. Despite innovation and scaling production, synthetic nicotine remains three to four times more costly than tobacco-derived nicotine, although prices are gradually decreasing.
The primary challenge lies in labeling and distinguishing synthetic nicotine from its tobacco-derived counterparts.